Non Randomized Controlled TrialBrief Description Of Study The primary purpose of this study is to determine the therapeutic effectiveness of Ifetroban to improve sinus and nasal symptoms and quality of life in subjects with Aspirin Exacerbated Respiratory Disease (AERD). Detailed Study Description This is a phase 2 multicenter, randomized, double-blind, placebo controlled study to evaluate the effects of 200 mg of oral ifetroban administered once daily for eight (8) weeks. Approximately 76 subjects will be randomized into two treatment groups of 38 subjects per group. One group will received the study drug ifetroban and the other will receive placebo. For inclusion in the study, patients must sign consent form and meet all of the criteria within 2 weeks of starting treatment. These subjects will be randomized into one of the treatment groups and receive treatment daily over the course of 8 weeks. Types Of Randomized Controlled TrialsThere are a total of five (5) required visits starting from screening, Visit 1 to post-treatment, visit 5. A patient diary will be used to record dates and times of all medication received to monitor compliance as well as frequency and severity of flare-ups, antibiotic and rescue medication use, and to record Total Nasal Symptom Scores twice daily. Additional Information About The Study Basic Eligibility Criteria • History of Physician-diagnosed asthma • History of nasal polyps • History of at least 2 reactions to oral aspirin or other Nonsteroidal anti-inflammatory drug (NSAID) with features of lower airway involvement (cough, chest tightness, wheezing, shortness of breath) or diagnosis of AERD via a physician conducted challenge to aspirin in the last 5 years before starting treatment. Phase 2 Randomised Controlled Trials Definition• Not currently smoking tobacco • Not currently pregnant or breastfeeding • Not currently taking Aspirin or any NSAID • No History of bleeding problems or taking other blood thinners • There are more potential exclusions which will be discussed with you if you are interested and meet the above criteria Site Location: Perelman Center for Advanced Medicine Department of Otorhinolaryngology 3400 Civic Center Blvd, 3rd Floor South Pavilion Philadelphia PA 19104 For further information contact: Laurel Doghramji, RN, BSN Study Coordinator at 215-615-1643 or [email protected]. 'This copy of windows must be activated with microsoft before you can log on. When logging on to my computer, I get the following message. Does anybody have any suggestions to help me fix this problem? This copy of windows must be activated with microsoft before you can log on crack. Do you want to activate windows now' I click 'yes', and it takes me back to the initial page to enter my name and password, and then back to the same message, 'This copy of windows.' Update: I am not able to get into the computer. Phase 2 Randomised Controlled TrialWe therefore proposed this randomized trial to evaluate the safety and efficacy of laparoscopic versus open gastrectomy for local advanced gastric cancer in patients aged 70 and above. METHODS: The current study has a randomized, parallel controlled, single-center, open-label, superiority design with two arms. In this multicenter phase 2 randomized controlled study, we evaluated the efficacy and safety of an ophthalmic suspension of PVP-I 0.6% and dexamethasone 0.1% for the treatment of acute adenoviral conjunctivitis in adults. Belimumab,an anti-BLyS antibody previously used in systemic lupus erythematosus,was studied in a double blind, randomised, placebo-controlled phase 2 trial. Belimumab was used in addition to standard of care immunosuppression in 25 adult kidney transplants.
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